ArticleClinical and translational allergy2026
Paucigranulocytic Asthma in Aspirin-Hypersensitive Patients: Pleiotropic Regulation of Type 2 Biomarkers.
Article in Clinical and translational allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUp to 50% of patients with nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) exhibit a noneosinophilic airway inflammatory phenotype, with paucigranulocytic asthma being the most prevalent. The aim was to identify clusters within N-ERD and aspirin-tolerant asthma (ATA) controls with a paucigranulocytic asthma phenotype.
methodsTwo separate hierarchical cluster analyses were performed using 23 variables in 36 N-ERD patients and 19 ATA controls. Variables included demographic, clinical, treatment-related, and hematologic parameters; sputum cytology; sinus computed tomography findings; and eicosanoid levels in induced sputum supernatant (ISS) and urine.
resultsTwo clusters were identified in each group: 1
conclusionTwo clusters were identified among N-ERD patients with a paucigranulocytic asthma phenotype. Cluster 1
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