Evidence map›Paper›PMID 42473059›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Wool Keratin-Engineered Manganese Nanozyme with Tumor Microenvironment-Adaptive Self-Cascade Capability for Hepatocellular Carcinoma Therapy.

Hongji Wu, Chaoyu Fan, Qikuan He, Zhenliu Qin, Feifei Huang, Wenxiu Zhao, Meilin Guo, Zhehao Han, Zonghao Dai, Zhisen Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hongji WuDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Chaoyu FanDepartment of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen, P. R. China.
Qikuan HeDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Zhenliu QinDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Feifei HuangDepartment of Ultrasonic Diagnosis, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Wenxiu ZhaoStrait Precision Medicine Center, School of Medicine, Zhongshan Hospital of Xiamen University, Xiamen University, Xiamen, P. R. China.ORCID https://orcid.org/0000-0002-1236-4173
Meilin GuoDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Zhehao HanDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Zonghao DaiDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Zhisen ZhangDepartment of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen, P. R. China.
Qiyu ZhangDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.
Yonghua TangDepartment of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen, P. R. China.
Youhui LinDepartment of Physics, Research Institute for Biomimetics and Soft Matter, Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen, P. R. China.
Jie ZhangDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, P. R. China.

Funding

111 Project B16029Fujian Provincial Natural Science Foundation of China 2025J011002Longyan City Science and Technology Plan Project 2025LYF1008Scientific Research Fund of Hunan Provincial Education Department KZ08127Wenzhou Scientific Research Foundation Y2023160Wenzhou Scientific Research Foundation Y20240356Zhejiang Provincial Natural Science Foundation LQN25H030010
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC), the predominant form of primary liver cancer, poses a substantial global health challenge with high mortality and poor therapeutic outcomes, especially in advanced stages. Current therapeutic approaches for HCC, including surgical resection, targeted therapy, immunotherapy, and radiotherapy, are often limited by drug resistance, systemic toxicity, and the complex tumor microenvironment (TME). Herein, we establish the first wool keratin-guided Mn

Indexed as

Carcinoma, HepatocellularKeratinsLiver NeoplasmsManganeseNanoparticlesTumor MicroenvironmentWoolAnimalsApoptosisCatalysisCell Line, TumorHumansOxidesReactive Oxygen SpeciesKeratinsManganeseOxidesReactive Oxygen Specieshepatocellular carcinomananozymesreactive oxygen speciestumor microenvironmentwool keratin

Identifiers

PMID42473059
PMCPMC13580238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.