Evidence map›Paper›PMID 42473052›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Acoustic Tweezers-Assisted Biomaterial Molding in Petri Dishes (TAMP) for Engineering Glioma Tissues With Controlled Cellular and Extracellular Matrix Architectures.

Yingshan Du, Jiali Li, Hui Liu, Julio P Arroyo, Luyu Bo, Bowen Cai, Teng Li, Zhide Wang, Chongpeng Qiu, Rafael Davalos and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yingshan DuDepartment of Biomedical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0009-0002-9306-2608
Jiali LiDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0009-0006-9432-3776
Hui LiuWeifang People's Hospital, Shandong Second Medical University, Weifang, Shandong, China.ORCID 0000-0002-7173-1420
Julio P ArroyoWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology- Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-4690-6337
Luyu BoDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0009-0007-1629-4954
Bowen CaiDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0000-0002-6293-1041
Teng LiDepartment of Radiology, Center for Ultrasound Research and Translation, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0009-0005-4007-6012
Zhide WangDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0009-0004-5854-4569
Chongpeng QiuDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0009-0009-6641-7339
Rafael DavalosWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology- Emory University, Atlanta, Georgia, USA.ORCID 0000-0003-1503-9509
Joseph RichDepartment of Chemical and Biological Engineering, Brigham Young University, Provo, Utah, USA.ORCID 0000-0002-6249-2093
Zhenhua TianDepartment of Mechanical Engineering, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.ORCID 0000-0002-1903-5604

Funding

National Science Foundation Graduate Research Fellowship 2139754Virginia Tech ICTAS EFO-O Seed Investment 182323
6 · The paper itself

Abstract

Tissue engineering has shown great potential for manufacturing tissue replacements and developing physiologically relevant tissue models. However, conventional tissue engineering strategies often face challenges in fabricating tissues simultaneously incorporating controlled cellular and extracellular matrix (ECM) architectures. Here, we introduce Acoustic Tweezers-Assisted Biomaterial Molding in Petri Dishes (TAMP), enabling tissue fabrication with controlled cellular and ECM architectures in Petri dishes, specifically, producing constructs with customized ECM geometries and various internal cellular architectures, including parallel elongated cell bundles, arrays of interconnected cell spheroids, and lattice-like cellular networks. TAMP leverages a portable acoustic array that delivers standing waves into a Petri dish or a polydimethylsiloxane (PDMS) mold, thereby enabling a unique "dual-control" mechanism. The acoustic field arranges internal cells into parallel line-like and lattice-like patterns, while the PDMS mold defines the overall ECM geometry. Our approach was demonstrated by arranging micro-objects into various patterns within different-shaped molds and fabricating glioma tissues with various unique internal cellular architectures, including parallel elongated glioma tissue bundles, lattice-like glioma tissue networks, and chains of interconnected glioma spheroids. We anticipate the TAMP technique will lead to portable, easy-to-operate tools for engineering tissues with controlled cellular and ECM architectures for biomedical research, disease modeling, and drug testing.

Indexed as

AcousticsBiocompatible MaterialsExtracellular MatrixGliomaTissue EngineeringCell Line, TumorDimethylpolysiloxanesHumansbaysilonBiocompatible MaterialsDimethylpolysiloxanesacoustic tweezers‐assisted tissue engineeringelongated glioma tissue bundlesengineered glioma tissue networksinterconnect glioma spheroid chainstissues with controlled cellular and matrix architectures

Identifiers

PMID42473052
PMCPMC13548918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.