Evidence map›Paper›PMID 42473035›Full record

ArticleCancer medicine2026

Inhibition of the Metalloproteinase ADAMTS5 Suppresses Colorectal Cancer Metastasis via the PEDF/Wnt/β-Catenin Pathway.

Xuan Sun, Hanqing Zhang, Yan Hu, Shengyu Jiao, Zesheng Yao, Ke Yi, Guojian Gu, Xiaohui Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xuan SunDepartment of Gastroenterology, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.ORCID https://orcid.org/0009-0008-8487-5096
Hanqing ZhangDepartment of Pathology, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.
Yan HuCentral Laboratory, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.
Shengyu JiaoDepartment of Gastroenterology, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.ORCID https://orcid.org/0009-0002-8535-7000
Zesheng YaoDepartment of Gastroenterology, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.
Ke YiCentral Laboratory, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.
Guojian GuDepartment of Pathology, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.
Xiaohui XuDepartment of Gastroenterology, The First People's Hospital of Taicang, Taicang Affiliated Hospital of Soochow University, Suzhou Medical College of Soochow University, Suzhou, China.

Funding

Guiding Project of Jiangsu Provincial Health Committee Z2021077Suzhou City Government Mandated Project on Healthcare Technology Innovation, New Clinical Diagnosis and Treatment Technologies, and Public Health SKY2022029Suzhou City Key Project for Advancing Health through Science and Education ZDXM2024018Suzhou Key Laboratory of Geriatric Neurological Disorders SZS2024001Taicang City Government Mandated Project on Medical Technology Research TC2023JCYL24
6 · The paper itself

Abstract

At present, colorectal cancer (CRC) ranks as the third most prevalent cancer globally and is the second most common cause of mortality associated with cancer. The expression of A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 (ADAMTS5) is upregulated in CRC, and high ADAMTS5 expression strongly correlates with an unfavorable prognosis. However, the function of ADAMTS5 in CRC remains unknown. This study aimed to investigate the role of ADAMTS5 in CRC and its potential mechanisms of action. The results showed that ADAMTS5 expression was higher in CRC tissues than in paracancerous tissues. Bioinformatics analysis revealed that its expression gradually increased with tumor progression and that high expression was correlated with poor prognosis. ADAMTS5 knockdown suppressed the proliferation and migration of HCT116 and HT29 cells, and ADAMTS5 inhibition suppressed epithelial-mesenchymal transition (EMT) in HCT116, HT29, and patient-derived organoids. Mechanistic analysis using the STRING database revealed that ADAMTS5 expression was strongly correlated with the Wnt signaling pathway. Western blotting analysis confirmed that ADAMTS5 inhibition suppressed tumor cell invasion and migration and blocked EMT in vitro through the PEDF/Wnt/β-catenin pathway. Furthermore, ADAMTS5 inhibition significantly inhibited tumor proliferation and metastasis within a nude mouse CRC liver metastasis model. These findings indicated that inhibition of ADAMTS5 could suppress CRC progression and metastasis via the PEDF/Wnt/β-catenin pathway.

Indexed as

ADAMTS5 ProteinColorectal NeoplasmsEye ProteinsNerve Growth FactorsSerpinsWnt Signaling PathwayAnimalsbeta CateninCell MovementCell ProliferationEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticHCT116 CellsHT29 CellsHumansADAMTS5 ProteinADAMTS5 protein, humanbeta CateninEye ProteinsNerve Growth FactorsPigment Epithelium-Derived FactorSerpinsADAMTS5colorectal cancerEMTmetastasisWnt/β‐catenin

Identifiers

PMID42473035
PMCPMC13381725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.