ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Allergic rhinitis is the strongest independent predictor of obstructive sleep apnea severity in preschool children.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveIt is known that both adenoid hypertrophy (AH) and allergic rhinitis (AR) can cause obstructive sleep apnea (OSA), but their relative importance, especially when tonsil size is considered, remains unclear. This study aimed to compare the independent contributions of AR, AH, and tonsil hypertrophy to OSA severity and to determine the primary contributing factor.
methodA total of 177 children aged 3 to 6 were included in the study. They were divided into four groups based on adenoid size (nasal endoscopic obstruction ≥ 75%) and AR (serum total IgE, inhalant-specific IgE, or clinical diagnosis): Group A (AH alone, n = 39), Group B (mixed factors, n = 63), Group C (AR alone, n = 53), and Group D (control, n = 22). OSA severity was assessed using the apnea-hypopnea index (AHI) measured by polysomnography. Intergroup comparisons were performed using the Kruskal-Wallis test. Spearman's correlation analysis was used to evaluate the correlation between total IgE and AHI. A multivariate linear regression model was employed to identify independent predictors of ln_AHI.
resultThe AHI in Group B was significantly higher than that in Groups A, C, and D (P < 0.05). Total IgE showed a weak but significant positive correlation with AHI (r_s = 0.15, P = 0.042). AR was the strongest independent predictor of ln_AHI (standardized β = 0.258, 95% CI: 0.095-0.311, P < 0.0001), followed by tonsil size, BMI, adenoid size and gender, while age was not statistically significant.
conclusionAmong preschool children, AR is the strongest independent predictor of OSA severity, followed by the size of the adenoid and tonsil. Clinically, for preschool children with OSA, assessing allergic status should be prioritized alongside evaluation of adenotonsillar anatomy, and anti‑allergic therapy should be considered as a key component of OSA management, either as a stand‑alone treatment in mild cases or as an adjunct to adenotonsillectomy in more severe cases.
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