ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Comprehensive evaluation of angiogenesis-associated genes in papillary thyroid cancer using bulk RNA and single-cell sequencing data.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe objective of this study is to explore the expression patterns of angiogenesis-related genes in papillary thyroid cancer (PTC) to enhance understanding of the molecular mechanisms underlying angiogenesis in this malignancy. The findings provide valuable insights into the development of therapeutic strategies.
methodsAngiogenesis related genes in tumor and adjacent tissues of PCT were analyzed in public database. Immune and cluster analysis were performed on differentially expressed genes, machine learning to obtain key markers, and diagnostic model has been established; Comparative analysis was conducted in tumor and adjacent tissues in PCT public database, combined with angiogenesis related pathways, to identify key cell subgroups and perform transcription factor analysis in tumor and adjacent tissues; The key markers were validated by qPCR.
results41 genes related to angiogenesis in tumors and adjacent tissues were obtained, including 8 differentially expressed genes (EMCN, PML, CANX, CDH13, SPHK1, IL18, VEGFA, and RHOB). Machine learning modeling was performed on the 41 angiogenesis related genes to obtain 6 key markers (EGF, CDH13, SPHK1, CANX, PML, and EMCN). Five genes with significant meaning (CDH13, SPHK1, CANX, PML, and EMCN) were identified and validated using qPCR on the tissues of our cohort, resulting in three genes with consistent expression (CDH13, SPHK1, EMCN).
conclusionThe biological process of angiogenesis plays an important role in the occurrence and development of PCT. CDH13, SPHK1, and EMCN may play an important roles.
Indexed as
Identifiers
42472943What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.