ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Heavy metal levels in malignant salivary gland tumours: a case-control study.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposePresence of toxic heavy metals such as lead (Pb) and chromium (Cr) and also low or high levels of essential heavy metals such as zinc (Zn) and copper (Cu) have detrimental health effects. However, malignant salivary gland tumours (MSGTs) have not been considered in this context. The etiopathogenesis of MSGTs and toxicity of heavy metals involve common mechanisms such as oxidative damage and chronic inflammation. The aim of this study was to investigate the possible relationship between MSGTs and heavy metals.
methodsA total of 60 participants (30 patients with MSGTs and 30 matched healthy controls) were investigated. Data including both serum and saliva heavy metal levels of patients and healthy controls were statistically compared. Standard solutions of the elements to be analysed (Fe, Zn, Cu, Mn, Cr, Pb) were prepared using increasing concentrations of 2% nitric acid solution. An inductively coupled plasma mass spectrometer was used for analysis.
resultsIn both serum and saliva, Fe levels were not different between patients and controls (p > 0.05), but significantly lower Zn (p < 0.001) and Cu (p ≤ 0.011) and higher Pb (p < 0.001) levels were found in patients compared to controls. Also, in saliva, significantly higher Mn (p < 0.001) and Cr (p < 0.001) levels were found in the patients compared to the controls.
conclusionsThis study revealed that patients with MSGTs are associated with lower levels of Zn and Cu, but higher levels of Pb in both serum and saliva. Furthermore, these cancers are associated with higher levels of Mn and Cr in saliva.
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