Evidence map›Paper›PMID 42472931›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Optimizing pathogen detection in skull base osteomyelitis: a comparative analysis of swab versus biopsy sampling.

Miriam Simon, Mara Wichtrup, Laurenz Althaus, Friederike Weise, Insa Joost, Jörg Schipper, Julia Kristin

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Miriam SimonDepartment of Otorhinolaryngology, Duesseldorf University Hospital, Moorenstrasse 5, Duesseldorf, 40225, Germany. Miriam.Simon@med.uni-duesseldorf.de.ORCID http://orcid.org/0000-0002-5116-8888
Mara WichtrupDepartment of Otorhinolaryngology, Duesseldorf University Hospital, Moorenstrasse 5, Duesseldorf, 40225, Germany.
Laurenz AlthausDepartment of Otorhinolaryngology, Duesseldorf University Hospital, Moorenstrasse 5, Duesseldorf, 40225, Germany.
Friederike WeiseDepartment of Otorhinolaryngology, Duesseldorf University Hospital, Moorenstrasse 5, Duesseldorf, 40225, Germany.
Insa JoostDepartment of Medical Microbiology and Hospital Hygiene, Duesseldorf University Hospital, Moorenstrasse 5, Duesseldorf, 40225, Germany.
Jörg SchipperDepartment of Otorhinolaryngology, Duesseldorf University Hospital, Moorenstrasse 5, Duesseldorf, 40225, Germany.
Julia KristinDepartment of Otorhinolaryngology, Duesseldorf University Hospital, Moorenstrasse 5, Duesseldorf, 40225, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSBO is a potentially life-threatening condition requiring multimodal treatment. For targeted antibiotic therapy, identification of the causative pathogen is essential. This paper aims to compare biopsy and swab techniques and assess their impacts on the initiation and adequacy of antibiotic therapy.

methodsA retrospective analysis was conducted on 56 adult patients treated for SBO 2008-2025. This study focuses on comparing intraoperative swab and biopsy specimens versus non-intraoperative swab specimens.

resultsThe most frequently detected organism in patients with typical SBO was Pseudomonas aeruginosa, accounting for 28.0% isolates from external auditory canal swabs and 23.7% of isolates from biopsy sites (patients with atypical SBO: 78.6%). Despite comprehensive sampling no microbiological pathogen could be isolated in 16.1% of patients.

conclusionPathogen-specific antibiotic therapy following tissue sampling is a cornerstone of SBO treatment. Accordingly, appropriate specimen collection plays a key role in selecting the correct antibiotic therapy.

Indexed as

OsteomyelitisSkull BaseSpecimen HandlingAdultAgedAnti-Bacterial AgentsBiopsyEar CanalFemaleHumansMaleMiddle AgedPseudomonas aeruginosaPseudomonas InfectionsRetrospective StudiesAnti-Bacterial AgentsAntibiosisBiopsyMultimodal approachPathogen detectionSkull base osteomyelitisSkull base surgerySwab

Identifiers

PMID42472931
PMCPMC13615056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.