ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Hyperuricemia beyond gout: an emerging risk factor for sensorineural hearing loss.
Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeHyperuricemia is a common metabolic condition with established systemic effects; however, its potential association with auditory dysfunction has not been clearly defined. This study aimed to evaluate hearing thresholds and cochlear outer hair cell function in individuals with hyperuricemia using subjective and objective audiological assessments.
methodsA comparative cross-sectional study was conducted involving 130 participants aged 30-55 years, comprising 65 hyperuricemic subjects and 65 age- and gender-matched normouricemic controls. Pure Tone Audiometry (PTA) was performed at frequencies from 250 to 8000 Hz. Distortion Product Otoacoustic Emissions (DPOAE) were recorded at 1000, 2000, 4000, 6000, and 8000 Hz, and signal-to-noise ratio (SNR) values were analyzed. Statistical analysis included Student's t-test, Mann-Whitney U test, and Chi-square test, with p < 0.05 considered statistically significant.
resultsMean PTA thresholds were higher in hyperuricemic subjects across all tested frequencies compared to controls, with statistically significant differences (p < 0.001). Mild sensorineural hearing loss was more frequently observed in the hyperuricemic group. DPOAE analysis demonstrated significantly reduced SNR values, particularly at higher frequencies, and a higher proportion of absent emissions in hyperuricemic subjects. No significant association was observed between hearing loss and age or duration of symptoms.
conclusionThe findings suggest an association between hyperuricemia and early cochlear dysfunction. Objective measures such as DPOAE may be useful for identifying subclinical auditory involvement in this population.
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