Evidence map›Paper›PMID 42472895›Full record

ArticleSeminars in dialysis

Topical Timolol for Peritoneal Dialysis Catheter Exit-Site Granulomas: First Report of Successful Use in CAPD Patients.

Veenaa Manjari S, Rajeevalochana Parthasarathy, Prashanth N, Bhavadharani Saravanan, Hemanath Krishnamoorthy

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In one paragraph

Article in Seminars in dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Veenaa Manjari SDepartment of Nephrology, Medway Hospitals, Chennai, India.ORCID 0009-0001-6725-4545
Rajeevalochana ParthasarathyDepartment of Nephrology, Medway Hospitals, Chennai, India.ORCID 0000-0003-2983-4554
Prashanth NDepartment of Nephrology, Medway Hospitals, Chennai, India.
Bhavadharani SaravananDepartment of Nephrology, Medway Hospitals, Chennai, India.
Hemanath KrishnamoorthyDepartment of Nephrology, Medway Hospitals, Chennai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exit-site granuloma is a frequent and challenging complication in patients undergoing peritoneal dialysis, predisposing to exit-site infections. Recent evidence suggests a potential role for topical timolol in promoting regression of granulomatous tissue. We report two patients on continuous ambulatory peritoneal dialysis who developed exit-site granulomas. Both patients were treated with topical 0.5% timolol maleate ophthalmic solution applied locally to the exit site three times weekly as part of routine exit-site care. Clinical response was monitored using serial photographs. Complete resolution of the granuloma was achieved within 3 weeks in one patient and within 2 months in the other. Neither patient developed local or systemic adverse effects, and no exit-site infections occurred during treatment. Topical 0.5% timolol maleate may represent a safe, non-invasive, and effective treatment option for peritoneal dialysis exit-site granulomas. Larger studies are warranted to establish its efficacy in larger cohorts.

Indexed as

Adrenergic beta-AntagonistsCatheters, IndwellingGranulomaKidney Failure, ChronicPeritoneal Dialysis, Continuous AmbulatoryTimololAdministration, TopicalFemaleHumansMaleMiddle AgedOphthalmic SolutionsTreatment OutcomeAdrenergic beta-AntagonistsOphthalmic SolutionsTimololexit‐site granulomaexit‐site granuloma in PDperitoneal dialysistimolol for exit‐site granuloma

Identifiers

PMID42472895
PMCPMC13511375

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.