ReviewAnnals of general psychiatry2026
Efficacy of curcumin in depression: A grade-assessed systematic review and meta-analysis of randomized controlled trials.
Review in Annals of general psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular Signaling Pathways in Depression and Neuroinflammation: Focus on New Pathophysiological Proteins and Therapeutic Compounds.Antioxidants (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundsCurcumin is a natural polyphenolic compound that is believed to have the potential to treat various ailments, including depressive mood. However, studies on the anti-depressive properties of curcumin have yielded conflicting results. This meta-analysis seeks to assess the clinical benefits of curcumin for patients with depression or depressive symptoms.
methodsWe systematically reviewed Scopus, PubMed, Web of Science, and Embase, inception February 15, 2025, to identify studies evaluating the impact of curcumin supplementation on depression in adults. The overall effects calculated using random effects model.
resultsNineteen RCTs were included in meta-analysis. A pooled analysis of eight studies showed a significant effect for curcumin supplementation in term of improving depression (SMD: -0.76; 95% CI: -1.22, -0.30, p = 0.001; I
conclusionsThis meta-analysis suggests that curcumin supplementation may improve depression and depressive symptoms significantly; however, due to sensitivity analysis the observed effect was fragile. Therefore, these findings should be interpreted with caution, and further high-quality trials are needed to determine its potential clinical efficacy.
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Registered trials
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