Evidence map›Paper›PMID 42472803›Full record

ArticleBMC pulmonary medicine2026

COPD is associated with poorer survival in patients with advanced non-small cell lung cancer treated with first-line ICI plus chemotherapy.

Akihisa Takano, Daisuke Shibahara, Hiroaki Ogata, Sai Yasukochi, Ryosuke Matsukane, Toshifumi Ninomiya, Takahiro Utsumi, Yuki Ikematsu, Kohei Otsubo, Yoshimasa Shiraishi and 3 more

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Akihisa TakanoDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Daisuke ShibaharaDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. shibahara.daisuke.805@m.kyushu-u.ac.jp.
Hiroaki OgataDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Sai YasukochiDepartment of Pharmacy, Kyushu University Hospital, Fukuoka, Japan.
Ryosuke MatsukaneDepartment of Pharmacy, Kyushu University Hospital, Fukuoka, Japan.
Toshifumi NinomiyaDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Takahiro UtsumiDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yuki IkematsuDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Kohei OtsuboDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Yoshimasa ShiraishiDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Eiji IwamaDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Mayako UchidaDepartment of Pharmacy, Kyushu University Hospital, Fukuoka, Japan.
Isamu OkamotoDepartment of Respiratory Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) frequently coexists with non-small cell lung cancer (NSCLC). Previous studies suggest that COPD may be associated with improved outcomes in patients receiving immune checkpoint inhibitor (ICI) monotherapy, but its impact in patients treated with ICI plus chemotherapy remains unclear.

methodsIn this retrospective single-institution study, we evaluated 55 ever-smokers with stage IV NSCLC treated with first-line ICI plus chemotherapy who underwent pulmonary function testing. COPD was defined as a post-bronchodilator FEV

resultsIn unadjusted analyses, median PFS was 5.3 months in the COPD group and 11.1 months in the non-COPD group (hazard ratio [HR] 1.79, 95% confidence interval [CI] 0.95-3.37; p = 0.071). After IPTW adjustment, PFS was significantly shorter in the COPD group (median 4.6 months vs 13.7 months; HR 2.54, 95% CI 1.29-5.00; p = 0.007). In unadjusted analyses, median OS was 12.7 months in the COPD group and not reached in the non-COPD group (HR 1.56, 95% CI 0.73-3.33; p = 0.247). After IPTW adjustment, OS was significantly shorter in the COPD group (median 11.8 months vs not reached; HR 3.00, 95% CI 1.16-7.73; p = 0.023).

conclusionsCOPD may be associated with poorer survival among ever-smokers with advanced NSCLC receiving first-line ICI plus chemotherapy, although further validation in larger cohorts is warranted.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsCarcinoma, Non-Small-Cell LungImmune Checkpoint InhibitorsLung NeoplasmsPulmonary Disease, Chronic ObstructiveAgedFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm StagingProgression-Free SurvivalProportional Hazards ModelsRetrospective StudiesImmune Checkpoint InhibitorsChemotherapyChronic obstructive pulmonary diseaseImmune checkpoint inhibitorsNon-small cell lung cancerOverall survivalProgression-free survival

Identifiers

PMID42472803
PMCPMC13663149

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.