ArticleDiscover nano2026
Combined effects of Lenvatinib and zinc oxide nanoparticles by promoting apoptosis and anti-proliferative activity in mice bearing Ehrlich solid tumors.
Article in Discover nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThe objective of this study is to evaluate the anticancer activity of lenvatinib and zinc oxide nanoparticles (ZnO-NPs) separately and in combination and whether ZnO-NPs can reduce resistance to lenvatinib treatment.
methodsTEM, SEM, Zeta, DLS, UV, FTIR, and XRD performed to characterize ZnO-NPs. Fifty mature female Swiss albino mice bearing solid Ehrlich carcinoma (SEC) were randomly divided into five equal groups: Negative control, SEC, Lenvatinib, ZnO-NPs, and Lenvatinib + ZnO-NPs. All treatments were administered for 4 weeks.
resultsA decrease in tumor volume (458.6 mm
conclusionAccording to these results, zinc oxide nanoparticles may increase lenvatinib's anticancer effectiveness by promoting apoptosis and inhibiting proliferation. Future clinical research may employ the combination because it seems to be both safe and effective.
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