Evidence map›Paper›PMID 42472739›Full record

ArticleHeart and vessels2026

Elucidating physiologic influences of sleep-related breathing and architectural disruption in Takotsubo syndrome.

Sepideh Khazaie, Michael D Faulx, James F Bena, Shannon L Morrison, Alex Milinovich, Megan Sheehan, Lu Wang, Reena Mehra

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Article in Heart and vessels, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sepideh KhazaieLerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Michael D FaulxDepartment of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA. faulxm@ccf.org.ORCID http://orcid.org/0000-0002-6946-778X
James F BenaDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Shannon L MorrisonDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Alex MilinovichDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Megan SheehanDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Lu WangDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Reena MehraDepartment of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTakotsubo syndrome (TS), an acute stress-induced cardiomyopathy driven by catecholamine excess, shares pathophysiological features with sleep disordered breathing (SDB), yet this relationship remains unexplored. We hypothesize that SDB and sleep disruption influences TS risk and severity.

methodsWe leveraged data from the Cleveland Clinic sleep cohort (1999-2021) including patients with proven TS and matched controls (1:5 ratio by age, sex, body mass index (BMI), and study year). Logistic regression models were used to assess odds of TS associated with SDB biomarkers, i.e., apnea-hypopnea index (AHI; evaluated at thresholds ≥ 5, ≥15, and ≥ 30), hypoxia (percentage of sleep time with SaO

resultsS cases (n = 84; mean age 64.1 ± 11.4 years, 86.9% female, BMI 30.9 ± 7.7 kg/m

conclusionsMild OSA may be protective in TS, possibly via hypoxic preconditioning, while sleep fragmentation is associated with greater cardiac dysfunction. This first study of SDB in TS highlights a novel sleep-cardiac interplay, warranting further investigation.

Indexed as

Case-control studyCatecholamine excessHypoxic preconditioningLeft ventricular ejection fractionObstructive sleep apneaSleep disordered breathingSleep fragmentationTakotsubo syndrome

Identifiers

PMID42472739

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