ArticleTissue engineering and regenerative medicine2026
Long-Term Bone Healing Using Autogenous Tooth Bone Graft Combined with rhBMP-2 after Enucleation of a Large Odontogenic Keratocyst: A Case Report.
Article in Tissue engineering and regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAutogenous tooth bone graft (AutoBT), derived from extracted teeth, has emerged as a promising alternative for bone regeneration due to its osteoinductive and osteoconductive properties. Its structural and compositional similarity to bone supports physiologic bone regeneration, and it has been successfully applied in various clinical procedures. However, despite its increasing clinical application, evidence regarding the long-term outcomes of AutoBT in large cystic defects remains limited. CASE PRESENTATION: A 22-year-old woman presented with a 4-cm multilobular radiolucent lesion in the left mandible that was diagnosed as an odontogenic keratocyst (OKC). Following a period of decompression, cyst enucleation and bone grafting were performed using AutoBT combined with recombinant human bone morphogenetic protein-2 (rhBMP-2). Radiographic follow-up at 1.5 months, 1 year, and 3 years postoperatively demonstrated stable bone remodeling, reestablishment of the cortico-cancellous architecture, and no evidence of recurrence. The postoperative clinical course was uneventful.
conclusionThis case demonstrates successful long-term bone regeneration using AutoBT combined with rhBMP-2 in a large mandibular OKC defect. Although limited to a single case, these findings support the potential of AutoBT combined with rhBMP-2 as a reliable graft material for extensive jawbone lesions. Further studies are needed to validate its long-term efficacy and safety.
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