ArticleInternal and emergency medicine2026
Association between lipid comprehensive index and carotid atherosclerosis: evidence from a large-scale ultrasound screening program.
Article in Internal and emergency medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Carotid atherosclerosis (CA) has not been well characterized in relation to the Lipid Comprehensive Index (LCI) in middle-aged and elderly populations. This large-sample study aimed to examine the association between LCI and prevalent CA. This cross-sectional study analyzed data from 56,383 participants aged ≥ 40 years enrolled in the 2017-2020 Hubei Stroke Screening and Prevention Project. All participants underwent carotid ultrasonography for the evaluation of CA. LCI was calculated as [TC × TG × LDL-C/HDL-C]. Logistic regression and restricted cubic spline (RCS) modeling analyses were performed to examine the association of LCI, treated as both a continuous variable and quartiles, with CA. Subgroup analyses were conducted to explore effect modifications across various population characteristics. Logistic regression analysis showed that higher LCI levels were significantly associated with greater odds of CA, carotid intima-media thickening (CMT), plaque, and stenosis (all p
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