ArticleNeuroimage. Reports2026
Brain volumes in congenital heart disease from childhood to adulthood: A pooled neuroimaging study.
Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
Complex congenital heart disease (CHD) is associated with reduced brain volumes, but little is known about the brain developmental trajectory in CHD beyond childhood, which is a critical period for brain maturation. This study reports alterations in brain volumes from a large cross-sectional dataset of patients with CHD and controls, with an age range from childhood to young adulthood. Patients and controls underwent 3 T cerebral MRI and overlapping cognitive assessments. Images were processed using Freesurfer 5.3. The dataset comprised 311 participants, 128 CHD and 183 controls aged between 9 and 32 years (male: 52.1%). Associations between the total brain and grey matter, white matter, and cerebrospinal fluid (CSF) volumes and age, sex, group (CHD vs. controls) and maternal education were analysed using linear mixed models. Global and total grey/white matter volumes were smaller in patients with CHD compared to controls (
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