ArticleCureus2026
Simultaneous High-Grade Upper-Tract Urothelial Carcinoma and Xanthogranulomatous Pyelonephritis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
A 67-year-old female with a previous history of superficial urothelial carcinoma of the bladder, discharged from surveillance follow-up, presented to her general practitioner with nausea and unintentional weight loss. The patient had radiological findings of a poor nephrogram with significant perirenal inflammatory stranding and hydronephrosis secondary to conglomerate pelvic calcification. This was suggestive of xanthogranulomatous pyelonephritis (XGP) and possible malignant changes. The patient ultimately underwent a radical nephrectomy; subsequently, the specimen revealed high-grade T4 urothelial cell carcinoma with background XGP, with vascular invasion and positive margins, but no evidence of spread to regional lymph nodes. She was referred onwards to oncology for further treatment given her margin status and is undergoing an intense and prolonged course of surveillance follow-up. This is likely one of the first reported cases of advanced disease with such diagnostic difficulty and surgical complexity.
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