ArticleiScience2026
ATR activity regulates DNA replication and RNA polymerase II transcription during S-phase.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcription and replication both utilize DNA as a template. However, even though conflicts between transcription and replication can induce genome instability, recent data have shown that both coexist temporally and spatially. We have now identified that cells employ multiple mechanisms to control transcription activity in S-phase. Our data show that transcription can be regulated by reducing RNA polymerase II loading on genes or by accumulating it on the promoter and preventing its progress into the gene body; moreover, this can occur on all transcribed genes or only on those replicated at that moment, and all these regulations appear controlled by ATR activity. Finally, we found a correlation between the genes most affected in our system and those with altered expression in patients with cancer with deregulated ATR, potentially linking ATR's roles in regulating transcription activity during S-phase to phenotypes found in patients with cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.