ArticleiScience2026
Immunoregulatory properties of the human acellular amniotic membrane for diabetic wound healing.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repair of chronic diabetic wounds remains a major clinical challenge, and the immunoregulatory mechanisms of the human acellular amniotic membrane (HAAM) are not fully understood. Using a db/db type 2 diabetic mouse model with full-thickness dorsal wounds, this study evaluated the therapeutic effects of the HAAM compared with conventional gauze in wound healing. Compared with the control group, the HAAM group exhibited significantly accelerated wound closure and enhanced collagen deposition. Single-cell RNA sequencing revealed that the HAAM reshaped the immune microenvironment by promoting chemotactic, tissue-reparative macrophage phenotypes while reducing S100a9+ neutrophils linked to neutrophil extracellular traps. Intercellular communication analysis indicated enhanced macrophage-neutrophil interactions via Spp1-CD44 signaling. HAAM-treated wounds upregulated prodegenerative and angiogenic genes and exhibited balanced matrix remodeling. Overall, the findings indicated that the HAAM promoted diabetic wound healing by reducing excessive inflammation and activating regenerative pathways, highlighting its potential as a bioactive scaffold for next-generation immunomodulatory biomaterials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.