Evidence map›Paper›PMID 42472093›Full record

ArticleiScience2026

Cross-site oral and esophageal microbiome signatures define diagnostic patterns and reveal mechanistic drivers of ESCC.

Jin-Yu Kong, Yi-Jun Qi, Qi-Wei Liu, Hai-Jun Xu, Dang-Rou Wu, Ye-Lin Jiao, Pan Chen, Bian-Li Gu, Yi-Wen Liu, Hui Wu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jin-Yu KongHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Yi-Jun QiHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Qi-Wei LiuHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Hai-Jun XuHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Dang-Rou WuHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Ye-Lin JiaoHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Pan ChenHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Bian-Li GuHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Yi-Wen LiuHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.
Hui WuSchool of Dentistry Oregon Health & Science University, Portland, OR, USA.
Richard J LamontDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY 40202, USA.
Huizhi WangVCU Philips Institute for Oral Health Research, Department of Oral and Craniofacial Molecular Biology, Virginia Commonwealth University, Richmond, VA 23298, USA.
She-Gan GaoHenan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang Cancer Hospital, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 471003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral cavity and esophagus are contiguous mucosal sites whose microbiomes may jointly influence esophageal squamous cell carcinoma (ESCC). To address whether microbial alterations are shared across oral and esophageal niches and possess diagnostic potential in ESCC, we performed five-region 16S rRNA sequencing on paired oral swabs and esophageal tissues from 45 patients with ESCC and matched controls. We identified consistent enrichment of

Indexed as

CapnocytophagaCross-site oral-esophageal MicrobiomeESCCFusobacteriumImmune MicroenvironmentPorphyromonasPrognosisTreponema

Identifiers

PMID42472093
PMCPMC13380437

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.