ArticleClinical, cosmetic and investigational dermatology2026
Conceptual Approaches to Facial Lifting Using Hyaluronic Acid Fillers: An Anatomical and Biomechanical Perspective.
Article in Clinical, cosmetic and investigational dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This Perspective reviews contemporary approaches to hyaluronic acid (HA) filler-based facial lifting, focusing on how different strategies define anatomical treatment targets and propose underlying biomechanical mechanisms. A key contribution is the shift toward interpreting the continuous facial fibrous supporting network as a unified biomechanical unit-an aspect not emphasized in previous frameworks. HA fillers have become central to nonsurgical facial rejuvenation, with clinical applications expanding beyond focal volume correction toward structural and multidimensional interpretations of facial aging. Representative frameworks include myomodulation, which targets functional muscle balance; depth-oriented dual-plane strategies, which differentiate structural support by injection depth; and retaining ligament-targeted approaches, which define focal anchoring structures as anatomical treatment targets. Although these frameworks share a recognition of structural elements as key therapeutic targets, they differ substantially in their mechanistic interpretations and each addresses discrete layers, functional units, or focal structures-leaving underexplored the anatomical continuity and collective biomechanical role of the facial fibrous supporting network as a unified system. These approaches are summarized from anatomical and biomechanical perspectives, and an integrative interpretive framework is proposed in which the continuous fibrous supporting network is reconsidered as a unified therapeutic unit, offering a structural basis for reinterpreting facial lifting with HA fillers and for future clinical application and research design. This review aims to provide a structural and functional basis for reinterpreting facial lifting with HA fillers and to support future clinical application and research design. The fibrous network-oriented framework discussed herein is intended as a hypothesis-generating model that requires prospective validation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.