ArticleHemaSphere2026
Hemophagocytic lymphohistiocytosis-like syndrome after CD19-directed CAR T-cells for B-cell lymphoma and B-cell acute lymphoblastic leukemia: A LYSA, SFCE, and GRAALL study from the DESCAR-T registry.
Article in HemaSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04328298 (French Register Of Patients With Hemopathy Eligible For CAR-T Cell Treatment), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
French Register Of Patients With Hemopathy Eligible For CAR-T Cell Treatment (DESCAR-T)
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0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
30 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are well-recognized toxicities of CAR T-cell therapy, immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome (IEC-HS) remains poorly characterized. We aimed to describe the incidence, clinical features, management, and outcomes of IEC-HS using real-world data from the DESCAR-T registry (NCT04328298). We conducted a multicenter retrospective study of patients registered in DESCAR-T who received standard-of-care CD19 CAR T-cell therapy for relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL) or B-cell acute lymphoblastic leukemia (B-ALL) and fulfilled ASTCT criteria for IEC-HS. We analyzed 42 patients who developed IEC-HS. Most had a high CAR-HEMATOTOX score (≥2,
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Registered trials
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