Ratiometric nitric oxide fluorescent probe in the second near infrared window for the visualization of inflammation.

Ruixun Chen, Ranran Guo, Zhiyuan Wang, Weiping Yang, Jiachun Lin, Yutao Zeng, Ye Tian

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Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Ruixun ChenBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.

Ranran GuoSchool of Biomedical Engineering, Guangzhou Institute of Cancer Center Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, 510182, China.

Zhiyuan WangBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.

Weiping YangBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.

Jiachun LinDepartment of Pediatrics, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China.

Yutao ZengBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.

Ye TianBiomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitric oxide (NO), a key inflammatory mediator, plays dual roles in both immune response and inflammatory progression. Real-time, dynamic monitoring of NO levels in vivo is therefore essential for elucidating related pathological pathways. To address this challenge, we developed a ratiometric fluorescent probe, CSQD@PIB, with emission in near-infrared-II window (NIR-II) for the visualization of NO in inflammation models. This probe integrates two luminescent components: lead sulfide core-shell quantum dots (CSQD) emitting in the 1500-1700 nm band as an invariant internal reference for spatial localization and a NO-responsive conjugated polymer (PIB) exhibiting specific fluorescence enhancement in the 1000-1300 nm band as a quantitative sensing unit. By correlating the intensity ratio of the two emission channels, the probe enables simultaneous, real-time visualization and quantification of NO in the inflammatory site. Experiments demonstrate that CSQD@PIB can monitor the dynamics of NO generation in various pathophysiological processes in vivo, providing a reliable, self-calibrating imaging tool with high signal-to-noise ratio for NO-related studies in living mammals.

Indexed as

InflammationNear-infrared imagingNitric oxideRatiometric imaging

Identifiers

PMID42472012

DOI10.1016/j.mtbio.2026.103438

PMCPMC13380070

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