ReviewBiological psychiatry global open science2026
Retinal Origins of Aberrant Salience in Schizophrenia: The Perceptual Theory.
Review in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Further Evidence Is Needed to Support the Perceptual Theory of Schizophrenia.Biological psychiatry global open science · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In schizophrenia research, visual processing abnormalities have traditionally been viewed as downstream consequences of cortical dysfunction. However, the epidemiological observation that congenital cortical blindness appears to confer protection against schizophrenia, while peripheral blindness, regardless of its developmental timing, does not, indicates that visual input itself may play a more fundamental role in disease pathogenesis. Here we propose the Perceptual Theory of Schizophrenia (PerTh), a framework positing that instability in retinal dopamine signaling acts as an initiating mechanism in a subset of individuals. Retinal dopamine functions as a master gain controller, modulating receptive field properties and spatial frequency processing through D
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.