Evidence map›Paper›PMID 42471956›Full record

ArticleCytotechnology2026

Evaluation of a prototype bioreactor based on slowly rotating drum.

Alfredo Ambrico, Mario Trupo, Rosaria Alessandra Magarelli, Vincenzo Larocca, Maria Martino, Sergio Modenese, Sirio Vurro

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alfredo AmbricoDepartment for Sustainability, Trisaia Research Center, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rotondella, 75026 Italy.
Mario TrupoDepartment for Sustainability, Trisaia Research Center, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rotondella, 75026 Italy.ORCID https://orcid.org/0000-0002-2640-050X
Rosaria Alessandra MagarelliDepartment for Sustainability, Trisaia Research Center, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rotondella, 75026 Italy.
Vincenzo LaroccaDepartment for Sustainability, Trisaia Research Center, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rotondella, 75026 Italy.
Maria MartinoDepartment for Sustainability, Trisaia Research Center, ENEA-Italian National Agency for New Technologies, Energy and Sustainable Economic Development, Rotondella, 75026 Italy.
Sergio ModeneseEco-Sistemi Srl, Rovereto, 38068 Italy.
Sirio VurroEco-Sistemi Srl, Rovereto, 38068 Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, an innovative rotating-drum bioreactor was evaluated and compared with a conventional stirred-tank system for CHO cell fed-batch culture, with particular focus on oxygen transfer, hydrodynamic conditions, and overall bioprocess performance. The novel configuration, based on a slowly rotating perforated drum, enabled efficient oxygenation at low rotational speeds, achieving a higher volumetric mass transfer coefficient (k Graphical abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s10616-026-01036-1.

Indexed as

BiopharmaceuticalsBioreactorsChinese hamster ovary (CHO) cellsMonoclonal antibodies (mAbs)Volumetric mass transfer coefficient (kLa)

Identifiers

PMID42471956
PMCPMC13379560

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.