ArticleIranian biomedical journal2026
Therapeutic Effects of Vernonia amygdalina on Oxidative Stress and Histopathological Damage in Pancreatic Toxicity Induced by 1,2-dimethylhydrazine in Wistar Rats
Article in Iranian biomedical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: 1,2-Dimethylhydrazine (DMH) induces pancreatic oxidative stress via reactive oxygen species overproduction and antioxidant depletion. Given the rich phytochemical and antioxidant properties of Vernonia amygdalina, this study investigated its therapeutic effects in inhibiting oxidative stress and histopathological damage induced by DMH in Wistar rats. Methods: Adult male Wistar rats were divided into different groups and exposed to DMH via the intraperitoneal route. Animals received oral administration of V. amygdalina ethanol extract at low (200 mg/kg) and high (400 mg/kg) doses, both before and after DMH exposure. The pancreatic tissues were then subjected to biochemical analysis and histopathological examination using standardized protocols. Results: The administration of V. amygdalina significantly attenuated body weight loss in both the pre- and post-treatment groups. Furthermore, it significantly improved (p < 0.05) the levels of total protein, amylase, nitric oxide, catalase, superoxide dismutase, malondialdehyde, glutathione peroxidase, glutathione (GSH), and glutathione reductase and reduced GSH percentages compared to the DMH group. The pancreatic tissues from DMH-induced rats treated with V. amygdalina showed a significant reduction (p < 0.05) in organ weight compared to the DMH group. Histological studies revealed the protective and regenerative effects of V. amygdalina on pancreatic tissues. Conclusion: This study indicates that V. amygdalina can effectively suppress irregularities in pancreatic function and oxidative stress induced by DMH toxicity due to its antioxidant properties. This observation implies that V. amygdalina holds promise as a novel therapeutic strategy for improving DMH systemic toxicity in animal models and could serve as a benchmark for future clinical trials.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.