Evidence map›Paper›PMID 42471731›Full record

ArticleJournal of medical case reports2026

Toripalimab-induced isolated ACTH deficiency associated with gastroparesis: a case report.

Chicheng Lu, Weijie Li, Qiyong Li

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chicheng LuDivision of Hepatobiliary and Pancreatic Surgery, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Weijie LiZhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Qiyong LiDivision of Hepatobiliary and Pancreatic Surgery, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. zjliqiyong@163.com.ORCID https://orcid.org/0000-0001-7203-3707

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint inhibitors can cause isolated ACTH deficiency, a rare condition often misdiagnosed due to nonspecific symptoms. We report a cholangiocarcinoma patient on toripalimab and lenvatinib who experienced recurrent gastrointestinal symptom and precordial discomfort for 2 years, mistakenly attributed to drug toxicity or functional disorders. Following surgery, the patient developed refractory delayed gastric emptying, during which IAD was identified through negative imaging examinations, low ACTH and cortisol levels. Glucocorticoid replacement rapidly resolved symptoms. This case highlights that persistent unexplained somatic complaints in ICI-treated patients warrant endocrine evaluation to avoid diagnostic anchoring and recognize atypical presentations of adrenal insufficiency.

Indexed as

Adrenocorticotropic HormoneGastroparesisEndocrine System DiseasesGenetic Diseases, InbornHumansHydrocortisoneHypoglycemiaTreatment OutcomeAdrenocorticotropic HormoneHydrocortisoneCase reportCortisolGastroparesisImmune checkpoint inhibitorIsolated ACTH deficiency

Identifiers

PMID42471731
PMCPMC13663009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.