Evidence map›Paper›PMID 42471705›Full record

Trial reportJournal of ovarian research2026

Multi-omics analysis reveals the effects of Jinfeng pills on the outcomes of IVF-ET in patients with poor ovarian response: a randomized controlled trial.

Xumei Kong, Qianwen Luo, Tianhong Huang, Furui Chen, Yanan Zhang, Dongsheng Xiong, Yu Qiu, Wei Lai, Xiaoyan Yan, Fangyi Long and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of ovarian research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xumei Kong *Reproductive Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Qianwen Luo *Laboratory Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Tianhong HuangDepartment of Medical Genetics and Prenatal Diagnosis, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Furui ChenReproductive Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Yanan ZhangReproductive Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Dongsheng XiongReproductive Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Yu QiuReproductive Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Wei LaiReproductive Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Xiaoyan YanCollege of Pharmacy, Chengdu Medical College, Chengdu, Sichuan, 610000, China.
Fangyi LongLaboratory Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China. Longfangyi1206@163.com.
Yan GongReproductive Medicine Center, Sichuan Provincial Women's and Children's Hospital, The Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, 610000, China. gongyan0619@163.com.

Funding

National Center for Women and Children's Health, the China CDC "Maternal and Infants Nutrition and Health Research Programs" 2023FYH012Natural Science Foundation of Sichuan Province 2024NSFSC0695Scientific and Technological Innovation Project of the Sichuan Maternal and Child Health Care Association 22FXZD01Scientific Research Project of the Chengdu Municipal Health Commission 2022155Scientific Research Project of the Sichuan Medical Association S22015
6 · The paper itself

Abstract

backgroundJinfeng pills (JFP), a well-known traditional Chinese medicine (TCM) consisted of 9 herbs, benefit Qi, nourish the blood, effectively regulate the menstrual cycle, promote ovulation and improve endometrial thickness and blood flow. Previous studies have shown that JFP has certain effect on premature ovarian insufficiency (POI). In this prospective cohort study, the effect and mechanisms of JFP on the outcomes of in vitro fertilization and embryo transfer (IVF-ET) in poor ovarian response(POR) was investigated.

methodsPatients diagnosed with POR based on the Bologna criteria were prospectively randomized into two groups: the JFP group and the POR group. Young patients with normal ovarian reserve were included in the Control (Con) group. The live birth rate (LBR), levels of estradiol (E

resultsCompared with the Con group, the POR group presented significantly lower levels of E

conclusionJFP enhances the ovarian levels of steroid hormones in poor ovarian responders undergoing IVF-ET. The therapeutic effects of JFP may involve the regulation of ALPL, HPSE, KRT1, LDLR, METTL7B, TGFBI, TMOD1, and the glycosaminoglycan degradation pathway.

Indexed as

Drugs, Chinese HerbalEmbryo TransferFertilization in VitroAdultEstradiolFemaleFollicular FluidHumansInsulin-Like Growth Factor IMolecular Docking SimulationMultiomicsOvulation InductionPregnancyProteomicsTreatment OutcomeDrugs, Chinese HerbalEstradiolInsulin-Like Growth Factor IIn vitro fertilizationJinfeng pillsLive birthPoor ovarian responseSteroid hormone

Identifiers

PMID42471705
PMCPMC13670681

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.