ArticleBMC complementary medicine and therapies2026
In vitro inhibitory effects of Hypoxis hemerocallidea and Pentanisia prunelloides on α-amylase, α-glucosidase and pancreatic lipase activities associated with obesity-related metabolic disorders.
Article in BMC complementary medicine and therapies, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a complex metabolic disorder associated with dysregulated lipid metabolism and impaired adipose tissue function, resulting in the development of various chronic diseases such as diabetes mellitus. Plant-based therapeutic strategies, targeting the inhibition of digestive enzymes, have gained increasing attention as potential safe alternatives to synthetic drugs. This study investigated the inhibitory effect of root and leaf extracts of Hypoxis hemerocallidea Fisch., C.A.Mey. & Avé-Lall. and Pentanisia prunelloides (Klotzsch ex Eckl. & Zeyh.) Walp, against α-amylase, α-glucosidase, and pancreatic lipase, and related these activities to metabolite profiles to explore their potential relevance in obesity-associated metabolic dysfunctions. The results showed that H. hemerocallidea leaves exhibited a strong inhibitory activity against pancreatic lipase (98.68%) and α-glucosidase (98.10%), while α-amylase was considerably lower (11.71%). In P. prunelloides, both roots and leaves showed a strong α-glucosidase inhibitory activity of 99.02% and 96.38%, respectively. Moderate α-Amylase inhibitory activity was observed in the roots of H. hemerocallidea (53.14%), and P. prunelloides (50.63%), with the inhibition levels comparable to the lipase standard inhibitor acarbose (55.65%). Metabolite profiling using liquid chromatography-mass spectrometry (LC-MS) analysis revealed diverse putatively identified bioactive metabolites, including flavonoids, phenolic acids, phenolic glycosides, proanthocyanidins, saponins, terpenoids, and xanthones. Correlation and multivariate analyses suggested potential associations between metabolite abundance and enzyme inhibitory activities. Collectively, these findings suggest that both plant species possess substantial metabolite diversity and promising in vitro enzyme inhibitory activities, with H. hemerocallidea exhibiting comparatively stronger inhibitory activity. However, no compound isolation, cytotoxicity assessment, and in vivo validation was performed; therefore, the findings should be considered preliminary and require further pharmacological and mechanistic investigation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.