Evidence map›Paper›PMID 42471672›Full record

ArticleBMC health services research2026

Financial impact of participating in oncology clinical trials in a tertiary hospital in Spain.

Sergio Mosquera-Ferrer, Emilio Vargas-Castrillón, Macarena Torrego-Ellacuría

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Article in BMC health services research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sergio Mosquera-FerrerClinical Pharmacology, Hospital Clínico San Carlos, Calle del Prof Martín Lagos, S/N, Madrid, 28040, Spain. sergiomosqueraferrer@gmail.com.ORCID http://orcid.org/0009-0008-5419-2112
Emilio Vargas-CastrillónClinical Pharmacology; Pharmacology and Toxicology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.
Macarena Torrego-EllacuríaInnovation Unit, Hospital Clinico San Carlos, IdISSC, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to evaluate the financial impact, including medication-related costs and other costs, of conducting randomized controlled trials (RCTs) in the oncology department of a tertiary hospital.

methodsThis retrospective study included all clinical trials conducted in the oncology department from January 2018 to December 2023, regardless of the phase of clinical research or type of sponsor. The total avoided cost was calculated as the drug cost avoided minus other direct medical cost for activities performed in the hospital using data from the official publication of the autonomous community health authority.

resultsDuring the observation period, 197 clinical trials actively recruited 1,198 patients, 757 of whom completed their participation within the established timeframe and were dispensed trial medications. Drug cost avoidance totaled €25,899,148, with a median (interquartile range [IQR]) by trial of €61,034 (€5,280, €235,588). Both industry-sponsored and noncommercially sponsored studies were associated with drug cost avoidance with an absolute (relative) contribution to the total cost avoidance of €23,134,649 (89.3%) and €2,764,499 (10.7%), respectively. Other direct medical cost for activities performed in the hospital €3,274,099.80. The total cost avoidance was €22,625,048. There were large variations in cost avoidance depending on the type of tumor.

conclusionsAlthough there are large variations across types of tumors, overall, clinical trials performed at the medical oncology department of a tertiary university hospital are associated with high cost avoidance and could contribute to reducing hospital expenditures for the management of cancer.

trial registrationNot applicable.

Indexed as

NeoplasmsRandomized Controlled Trials as TopicTertiary Care CentersDrug CostsHumansRetrospective StudiesSpainCancerClinical trialsCost avoidanceCost savingsInvestigational drug

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.