Evidence map›Paper›PMID 42471544›Full record

Observational studyJournal of patient-reported outcomes2026

Measuring group‑ and individual‑level change of FACIT- fatigue, NFLymSI-18 and PROMIS fatigue measures (4a, 7a and 13a) in lymphoma.

Maja Kuharic, Kimberly A Webster, Anne R Zola, Maria E Corona, Elijah A Patten, Reem Karmali, Leo Gordon, Shuo Ma, John D Peipert, David Cella

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of patient-reported outcomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maja KuharicDepartment of Medical Social Sciences, Northwestern University, Chicago, USA. maja.kuharic@northwestern.edu.ORCID https://orcid.org/0000-0003-3696-9086
Kimberly A WebsterDepartment of Medical Social Sciences, Northwestern University, Chicago, USA.
Anne R ZolaDepartment of Medical Social Sciences, Northwestern University, Chicago, USA.
Maria E CoronaDepartment of Medical Social Sciences, Northwestern University, Chicago, USA.
Elijah A PattenDepartment of Medical Social Sciences, Northwestern University, Chicago, USA.
Reem KarmaliRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, USA.
Leo GordonRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, USA.
Shuo MaRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, USA.
John D PeipertCentre for Patient Reported Outcomes Research, University of Birmingham, Birmingham, UK.
David CellaDepartment of Medical Social Sciences, Northwestern University, Chicago, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFatigue significantly impacts quality of life in lymphoma patients. Multiple patient-reported fatigue measures are used in lymphoma research, including FACIT-Fatigue and PROMIS Fatigue instruments, but direct comparisons of their responsiveness and ability to detect individual-level change in this population are lacking. This study evaluated the responsiveness and sensitivity to individual-level change of Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue), Patient-Reported Outcomes Measurement Information System (PROMIS) Fatigue measures (4a, 7a, and 13a), and NFLyMSI-18 Lymphoma Symptom Index in patients with lymphoma. METHODOLOGY: In a prospective observational study, 102 lymphoma patients at an academic cancer center completed FACIT‑Fatigue, PROMIS Fatigue 4a, 7a, and 13a, and NFLymSI‑18 at baseline and again at 3 months (n = 89). Responsiveness was evaluated using standardized response means (SRMs) for patients classified as improved or worsened via clinical anchors: Patient Global Rating of Change, Patient Global Rating of Severity, Patient Global Rating of Severity Interference, and PRO-CTCAE severity and interference fatigue items. Individual-level change was evaluated using Reliable Change Index (RCI) and Likely Change Index (LCI).

resultsSRM magnitudes varied by anchor and direction of change. For improvement, FACIT-Fatigue and NFLymSI-18 showed consistent responsiveness (SRMs 0.67-1.01 and 0.62-0.89, respectively), while PROMIS measures showed more variability (SRMs 0.31-1.58). For worsening, PROMIS measures, particularly 4a and 13a, demonstrated larger SRMs (0.75-1.71) than FACIT-Fatigue (0.73-1.24) or NFLymSI-18 (0.57-0.84) for most anchors. LCI analyses identified reliable improvement in 31.5% of patients using FACIT-Fatigue and 24.7-33.7% with PROMIS, and reliable worsening in 24.7% using FACIT-Fatigue and 23.6-34.8% using PROMIS measures.

conclusionsAmong lymphoma patients, FACIT-Fatigue and PROMIS Fatigue measures are responsive to meaningful change, with somewhat differing magnitude estimates across anchors and direction of change. These findings support planning for the use and interpretation of these fatigue measures in future clinical trials.

Indexed as

FatigueLymphomaPatient Reported Outcome MeasuresQuality of LifeAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesSeverity of Illness IndexSurveys and QuestionnairesSymptom BurdenFACIT-fatigueFatigueIndividual-level changeLikely change indexLymphomaPatient-reported outcomesPROMISReliable change indexResponsiveness

Identifiers

PMID42471544

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.