Evidence map›Paper›PMID 42471537›Full record

ArticleJournal of neuro-oncology2026

Comparative analysis of stereotactic radiosurgery and microsurgery for vestibular schwannoma: a clinical and radiological evaluation.

Andre E Boyke, Tariq Al-Saadi, Simon A Menaker, Edward Robinson, Alan Nguyen, Michelot Michel, Brittany Morris, Younis Al-Mufargi, Behrooz Hakimian, Amin Mirhadi and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andre E BoykeDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA. andre.boyke@cshs.org.ORCID http://orcid.org/0000-0002-7485-0644
Tariq Al-SaadiDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Simon A MenakerDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Edward RobinsonDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Alan NguyenDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Michelot MichelDepartment of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Brittany MorrisDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Younis Al-MufargiDepartment of Surgery, Medical City for Military and Security Services, Muscat, Oman.
Behrooz HakimianDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Amin MirhadiDepartment of Radiation Oncology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Yu-Tung WongDivision of Otolaryngology-Head and Neck Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Mia E MillerDivision of Otolaryngology-Head and Neck Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
John S YuDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare radiographic and clinical outcomes of vestibular schwannoma management using stereotactic radiosurgery (SRS) and microsurgical resection, with emphasis on paired pre- and post-treatment changes in tumor size and patient outcomes.

methodsA retrospective review was conducted of 87 patients treated for vestibular schwannoma between 2013 and 2024 at a single tertiary center. Demographic, clinical, and radiographic variables, including hearing loss, facial weakness, brainstem compression, tumor area, and Koos grade, were analyzed. Tumor area was determined from radiology reports and compared using nonparametric statistical tests, with significance defined as p < 0.05.

resultsMicrosurgery achieved a median 76% reduction in tumor area, while SRS was associated with relative stability or modest growth (+ 5%) (p < 0.001). Post-treatment rates of hearing loss and facial weakness were similar between groups, suggesting that substantial tumor reduction following microsurgery was not associated with increased morbidity in this cohort. Koos grade correlated with both brainstem compression and hearing loss, with higher grades favoring surgical management (p = 0.049). In the Koos IV subset, surgery achieved significant tumor reduction without disproportionate postoperative deficits compared with lower grades.

conclusionMicrosurgery provides immediate and substantial tumor reduction without increased morbidity, while SRS maintains radiographic stability with favorable clinical outcomes. These findings underscore the complementary roles of both modalities and support the Koos classification as a practical and reliable framework for treatment selection.

Indexed as

MicrosurgeryNeuroma, AcousticRadiosurgeryAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeHearing preservationMicrosurgeryOutcomesStereotactic radiosurgeryTumor controlVestibular schwannoma

Identifiers

PMID42471537
PMCPMC13380556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.