Evidence map›Paper›PMID 42471480›Full record

ArticleMacromolecular bioscience2026

In Vivo Evaluation of Conductive Biopolymer-Based 3D Bioprinted Nerve Conduit in Sciatic Nerve Injury Repair.

Nasera Rizwana, Yogesh H S, Kaustubh Raundal, Janani Sriramakrishnan, Shounak De, Syed Sahal, Goutam Thakur, Ashwath Acharya, Vipul Agarwal, Manasa Nune

Abstract read
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In one paragraph

Article in Macromolecular bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nasera RizwanaManipal Institute of Regenerative Medicine, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Yogesh H SDepartment of Pharmacology, Bangalore Campus, NITTE College of Pharmaceutical Sciences (NITTE Deemed to Be University), Bangalore, Karnataka, India.
Kaustubh RaundalManipal Institute of Regenerative Medicine, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Janani SriramakrishnanManipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Shounak DeManipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Syed SahalDepartment of Pharmacology, Bangalore Campus, NITTE College of Pharmaceutical Sciences (NITTE Deemed to Be University), Bangalore, Karnataka, India.
Goutam ThakurManipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID https://orcid.org/0000-0002-1449-9581
Ashwath AcharyaDepartment of Hand Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Vipul AgarwalDepartment of Materials Science and Engineering, Monash University, Clayton, Victoria, Australia.ORCID https://orcid.org/0000-0002-6239-5410
Manasa NuneManipal Institute of Regenerative Medicine, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID https://orcid.org/0000-0001-5328-5693

Funding

Anusandhan National Research Foundation SRG/2019/002130CSIR-SRF 08/0602(23334)/2025-EMR-IDepartment of Science & Technology (DST), India - DST-FIST SR/FST/LS-I/2018/121MAHE-University of New South WalesManipal Academy of Higher EducationManipal Institute of Regenerative MedicineMinistry of Education (MoE), Ministry of Electronics and Information Technology (MeitY), and Nanomission, Department of Science and Technology (DST), Govt. of IndiaNational Health and Medical Research Council GNT1139060SERB-POWER research SPG/2021/003703UNSW Safety Net Fellowship
6 · The paper itself

Abstract

Peripheral nerve injury (PNI) is one of the most common conditions that occurs due to trauma and accidents. A successful peripheral nerve regeneration can potentially benefit from the use of conduits with adequate physical, mechanical, and biochemical cues to recapitulate the native neural microenvironment. We report an electroconductive 3D bioprinted nerve conduit fabricated using alginate/methylcellulose/reduced graphene oxide (Alg/MC/rGO) hydrogel. The incorporation of rGO rendered the hydrogel with improved electrical conductivity while maintaining good printability and shape fidelity through dual crosslinking using calcium chloride. rGO was characterized thoroughly to confirm its physicochemical characteristics. The optimized Alg/MC/rGO hydrogel showed shear-thinning behaviour required for extrusion bioprinting and 3D structures (grid and nerve conduit) were successfully printed. Physicochemical analysis of Alg/MC/rGO scaffolds confirmed the presence of rGO within the scaffolds. On analysing conductivity properties, it was observed that Alg/MC/rGO scaffolds showed conductivity values (∼7.5 × 10

Indexed as

BioprintingNerve RegenerationPeripheral Nerve InjuriesPrinting, Three-DimensionalSciatic NerveTissue ScaffoldsAlginatesAnimalsBiopolymersElectric ConductivityGraphiteHydrogelsMaleRatsRats, Sprague-DawleyAlginatesBiopolymersgraphene oxideGraphiteHydrogels3D bioprintingalginatemethylcelluloseperipheral nerve injuryreduced graphene oxide

Identifiers

PMID42471480
PMCPMC13380635

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.