Evidence map›Paper›PMID 42471467›Full record

ArticlePediatric research2026

Hemodynamic effect of delayed cord clamping versus early cord clamping in preterm twins using echocardiography: a prospective observational study.

Floriane Brief, Anie Lapointe, Gabriel Altit, Marie-Josée Raboisson, Isabelle Boucoiran, Andréanne Villeneuve

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Floriane BriefDivision of Neonatology, Department of Pediatrics, CHU de Sainte Justine, Université de Montréal, Montreal, QC, Canada.
Anie LapointeDivision of Neonatology, Department of Pediatrics, CHU de Sainte Justine, Université de Montréal, Montreal, QC, Canada.
Gabriel AltitDivision of Neonatology, Department of Pediatrics, Montreal Children's Hospital, McGill University, Montreal, QC, Canada.
Marie-Josée RaboissonDivision of Pediatric Cardiology, Department of Pediatrics, CHU de Sainte Justine, Université de Montréal, Montreal, QC, Canada.
Isabelle BoucoiranSchool of Public Health and Obstetrics and Gynecology department, Université de Montréal, Montreal, QC, Canada.
Andréanne VilleneuveDivision of Neonatology, Department of Pediatrics, CHU de Sainte Justine, Université de Montréal, Montreal, QC, Canada. andreanne.villeneuve@umontreal.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare echocardiographic metrics in preterm twins who underwent delayed cord clamping (DCC) versus early cord clamping (ECC).

methodsProspective observational cohort study conducted at CHU Sainte Justine in Montreal involving preterm neonates between 24 and 36 weeks of gestational age. Neonates with congenital malformations, twin-to-twin transfusion syndrome, and the need of ECC for resuscitation were excluded. Echocardiography assessed the systemic blood flow.

results63 twins were included: 47 neonates receiving DCC, and 16 undergoing ECC. Superior vena cava (SVC) blood flow was comparable between the DCC and ECC groups at 6-9 h (78 ± 26.9 vs. 62 ± 20.1 mL/kg/min; p = 0.08) and 24-48 h (106 ± 31.2 vs. 87 ± 23.1 mL/kg/min; p = 0.07). Left ventricular output (LVO) was higher in the ECC group at 24-48 h (153 ± 30 vs. 187 ± 66 mL/kg/min; p = 0.01). TAPSE Z-score was higher in the DCC group at 24-48 h (-0.1 ± 1.9 vs. -1.1 ± 2.2 cm, p = 0.04). Systolic velocity of the right ventricle lateral wall was higher in the DCC group.

conclusionIn preterm twins, DCC was associated with improved echocardiographic indicators of cardiovascular stability and improved right ventricular function suggesting a potential benefit of DCC in this population. IMPACT: This prospective study implies a potential benefit of delayed cord clamping in a population of preterm twins and suggests to perform delayed cord clamping in this population.

Identifiers

PMID42471467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.