ArticlePediatric research2026
"Necrotizing enterocolitis": a paradigm shift.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Routine probiotics and outcomes in infants < 29 weeks: a 13-year single-centre cohort with propensity-weighted sensitivity analyses.European journal of pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Necrotizing enterocolitis (NEC) reveals substantial heterogeneity in presentation and underlying mechanisms. Conventional diagnostic tools, especially radiographic criteria and Bell staging, fail to distinguish between biologically distinct forms of intestinal injury, leading to imprecise management and research practices. The continued search for universal biomarkers is hindered by a lack of NEC mechanistic clarity. This commentary discusses abandoning the monolithic "NEC" label in favor of a data-driven, cluster-based taxonomy that integrates clinical trajectories with multiomic analyses. Such a shift would enable mechanism-informed diagnoses, personalized interventions, and more meaningful clinical trials, ultimately improving care and outcomes for vulnerable neonatal patients. IMPACT: NEC diagnosis lacks precision, leading to overtreatment and research confusion. Bell staging and biomarkers fail due to the heterogeneity of the diagnosis. Moving to data-driven, mechanism-based classification will enable targeted, effective care and better research outcomes.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.