Evidence map›Paper›PMID 42471464›Full record

SynthesisLangenbeck's archives of surgery2026

Incidental parathyroidectomy risk in thyroid carcinoma patients undergoing thyroidectomy: a systematic review and meta-analysis.

Binzhu Wang, XiaoYi Long, Jianguo Chen, Shu Liu

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Binzhu Wang *Department of Pathology, Yibin Fifth People's Hospital/Nanxi District People's Hospital (Yibin), Nanxi District, Yibin City, Sichuan Province, 644100, People's Republic of China.
XiaoYi Long *Department of pathology Clinical Medical College, the First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, People's Republic of China.
Jianguo ChenDepartment of General Surgery, Yibin Fifth People's Hospital/Nanxi District People's Hospital (Yibin), Nanxi District, Yibin City, Sichuan Province, 644100, People's Republic of China.
Shu LiuThyroid and Breast Surgery, The First People's Hospital of Jingdezhen, Jingdezhen, Jiangxi, 333000, China. lusun202583@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncidental parathyroidectomy (IP) is an important complication of thyroidectomy, and its risk may differ between malignant and benign thyroid pathology. This study aimed to evaluate the association between malignant thyroid pathology and the risk of IP in patients undergoing thyroidectomy.

methodsA systematic review and meta-analysis was conducted in accordance with PRISMA guidelines. Scopus, PubMed/MEDLINE, Web of Science, Embase, and Google Scholar were searched from database inception to November 15, 2025. Eligible studies included cross-sectional, cohort, or case-control studies that compared the incidence of IP between patients with malignant and benign thyroid pathology after thyroidectomy. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Sensitivity analysis and assessment of publication bias were also performed.

resultsThirty-three studies comprising 8,062 patients with IP and 25,134 controls without IP were included. Malignant thyroid pathology was associated with significantly higher odds of IP than benign thyroid pathology (OR 1.58, 95% CI 1.30-1.92). In subgroup analyses, no statistically significant associations were observed for Hashimoto's thyroiditis (OR 1.29, 95% CI 0.95-1.74), papillary thyroid carcinoma (OR 1.29, 95% CI 0.90-1.83), or follicular carcinoma (OR 0.70, 95% CI 0.41-1.19). Sensitivity analysis showed that the overall findings were robust, and Egger's test did not indicate significant publication bias.

conclusionMalignant thyroid pathology was modestly associated with IP; however, substantial heterogeneity, residual confounding, and reliance on crude observational data suggest malignancy may primarily reflect operative complexity rather than an independent causal risk factor. Findings should therefore be interpreted as exploratory associative evidence.

Indexed as

ParathyroidectomyThyroidectomyThyroid NeoplasmsHumansIncidental FindingsRisk FactorsIncidental parathyroidectomyMeta-analysisThyroidectomyThyroid malignancy

Identifiers

PMID42471464
PMCPMC13661637

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.