ArticleHeart rhythm2026
Accumulation of chronic conditions in patients aged <65 years diagnosed with atrial fibrillation.
Article in Heart rhythm, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
backgroundMultimorbidity is common in atrial fibrillation (AF), particularly in older patients who generally have multiple cardiovascular (CV) and non-CV conditions.
objectiveTo describe how chronic conditions accumulate in younger patients with AF.
methodsPatients aged <65 years with incident AF from 2013 to 2019 (N = 3462) were matched 1:1 on age (±5 years) and sex to referents from the same community. Onset of 20 chronic conditions (6 CV-related and 14 non-CV) was ascertained from 3 years before index through December 31, 2022. Andersen-Gill models estimated associations between AF or referent status and accumulation of conditions.
resultsThe mean age was 55.1 (8.8) years for both patients with AF and referents; 70.9% were male. Before index, 24.8% of patients with AF had no chronic conditions, whereas 32.3% of referents had 0 conditions. The accumulation of conditions was accelerated in patients with AF compared with referents, with the strongest associations within the first year after diagnosis/index for both CV-related (hazard ratio [HR], 3.80; 95% confidence interval [CI], 3.30-4.37) and non-CV conditions (HR, 2.42; 95% CI, 2.14-2.74). Stronger associations were observed for CV-related conditions, in women, and in the youngest age group. After 1 year, increased accumulation of CV-related conditions for patients with AF was observed in women (HR, 1.36; 95% CI, 1.13-1.63) but not men, and for those aged <50 (HR, 1.50; 95% CI, 1.13-1.99) and 50-54 years (HR, 1.43; 95% CI, 1.09-1.86) only.
conclusionPatients aged <65 years with AF have an increased accumulation of chronic conditions compared with those without AF, in particular within the first year after AF diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.