ArticleSTAR protocols2026
Protocol for HIV-1 latency reversal using engineered bacteriophage T4 particles.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
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Abstract
A major barrier to curing HIV-1 is the latent viral reservoir in resting CD4+ T cells. Here, we present a protocol for preparing CD4-DARPin (designed ankyrin repeat protein)-T4 nanoparticles and their application to HIV-1 latency reversal in a model of HIV-1 latency. We describe steps for producing T4 capsid nanoparticles in E. coli and their decoration with the CD4-targeting DARPin ligand fused to the T4 outer capsid protein Hoc. We then detail procedures for assessing proviral reactivation using fluorescence readouts. For complete details on the use and execution of this protocol, please refer to Batra et al.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.