ArticleMolecular biotechnology2026
An R2R3-MYB Gene GhMYBPA of Gossypium hirsutum Promotes Proanthocyanidin Accumulation and Improves Heat Tolerance in Arabidopsis.
Article in Molecular biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
R2R3-MYB transcription factors are typical members of the MYB transcription factor family and have been extensively investigated as key regulatory factors in the flavonoid metabolic pathway of model plants. Nonetheless, research on the functional characterization of R2R3-MYB genes remains limited in cotton. Here, we identified an R2R3-MYB gene GhMYBPA, which demonstrates predominant expression in the leaves of the Gossypium hirsutum cultivar XinCai20 (XC20). The coding sequence of the GhMYBPA is 765 bp. It contains two conserved MYB domains and demonstrates a close evolutionary relationship with other characterized proanthocyanidin metabolic regulators. The GhMYBPA-GFP fusion protein is enriched in the nucleus, and GhMYBPA exhibits significant transcriptional activation properties. Downregulation of GhMYBPA led to a significant decrease in proanthocyanidin levels in cotton leaves, whereas upregulation of GhMYBPA in Arabidopsis produced the opposite phenotype. Additionally, Arabidopsis lines overexpressing GhMYBPA exhibited enhanced tolerance to heat stress, with a significant upregulation of stress-responsive genes. The findings lay a foundation for investigating the function of GhMYBPA in Gossypium hirsutum, particularly regarding its involvement in proanthocyanidin accumulation and heat stress response.
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