ArticleActa neurochirurgica2026
Surgical outcomes and predictors of recurrence following endoscopic endonasal marsupialization of Rathke's cleft cysts.
Article in Acta neurochirurgica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic endonasal marsupialization (EEM) has been widespread adopted as drainage-based techniques for treatment of Rathke's cleft cyst. However, the effectiveness of marsupialization patency and recurrence risk remains inadequately defined. This study evaluated the correlation between sustained marsupialization opening and recurrence-free survival following EEM, and identified independent predictors of recurrence.
methodsWe performed a retrospective analysis of 54 consecutive patients with symptomatic Rathke's cleft cysts in whom endoscopic endonasal marsupialization was intended between January 2017 and December 2022. All patients received standardized fenestrated dural substitute reconstruction to maintain drainage patency. Primary outcome was radiological recurrence, with marsupialization patency assessed via serial endoscopic examination. Clinical outcomes, complications, and recurrence predictors were analyzed using Kaplan-Meier survival analysis and Cox proportional hazards regression.
resultsAt median follow-up of 63 months, among 49 patients in whom marsupialization was achieved, patency was maintained in 45 patients (91.8%). Overall, radiological recurrence occurred in 9 of 54 patients (16.7%), with only 2 requiring reoperation. All 9 recurrences demonstrated closure of the cyst drainage, including 4 patients from succussful marsupialization, and 5 patients from intraoperative cerebrospinal fluid leak precluded marsupialization. Recurrence-free survival at 1, 2, and 3 years was 94.4%, 87%, and 83.3%, respectively. Multivariate analysis identified three independent predictors: preoperative visual impairment (HR 32.8, p = 0.003), histopathological inflammation (HR 10.6, p = 0.013), and T1 hyperintense signal (HR 8.5, p = 0.019). Most recurrences occurred within three years, suggesting incomplete suprasellar drainage as the primary mechanism.
conclusionsMaintenance of marsupialization patency represents the critical determinant of recurrence-free survival. Simple fenestrated dural substitute technique achieves favorable outcomes without requiring elaborate reconstruction. Visual impairment, inflammation, and T1 hyperintensity predict higher recurrence risk and warrant intensified surveillance. Future efforts should focus on preserving drainage patency when intraoperative cerebrospinal fluid leak occurs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.