Evidence map›Paper›PMID 42470495›Full record

ArticleEuropean journal of applied physiology2026

Six weeks stretching of lower limbs lowers blood pressure in hypertensive individuals.

Nicholas Toninelli, Alessandro Maloberti, Emiliano Cè, Cristina Giannattasio, Fabio Esposito

Abstract read
In one paragraph

Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Nicholas Toninelli *Department of Biomedical Sciences for Health (SCIBIS), University of Milan, Via Colombo 71, 20133, Milan, Italy.
Alessandro Maloberti *School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Emiliano CèDepartment of Biomedical Sciences for Health (SCIBIS), University of Milan, Via Colombo 71, 20133, Milan, Italy.
Cristina GiannattasioSchool of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy.
Fabio EspositoDepartment of Biomedical Sciences for Health (SCIBIS), University of Milan, Via Colombo 71, 20133, Milan, Italy. fabio.esposito@unimi.it.ORCID http://orcid.org/0000-0002-4420-2611

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies on healthy subjects suggest that 6-week passive stretching (PS) lowers blood pressure (BP) and arterial stiffness by enhancing vascular responsiveness in both stretched and non-stretched arteries. This study investigated whether a similar 6-week PS intervention applied to the lower limbs could elicit similar effects in patients with essential hypertension.

methods24 patients underwent assessments of central arterial stiffness (carotid-femoral pulse wave velocity, PWV

resultsNo changes occurred following the 6-week control period. After PS, systolic, diastolic, and mean BP decreased by 4.9(SD4.6)% (P < 0.001, ES = -0.99), 6.9(SD4.9)% (P < 0.001, ES = -1.43), and 3.7(SD6.2)% (P = 0.005, ES = -0.63), respectively. Peak Q̇

conclusionThese findings indicate that 6-week PS effectively reduces blood pressure in hypertensive patients, possibly due to improved vascular responsiveness in the stretched arteries and the combined effect of other mechanisms that cannot be identified individually. However, these benefits dissipate once the intervention is discontinued.

Indexed as

Blood PressureHypertensionLower ExtremityMuscle Stretching ExercisesAgedFemaleHeart RateHumansMaleMiddle AgedVascular StiffnessArterial stiffnessCardiovascular healthVascular responsiveness

Identifiers

PMID42470495
PMCPMC13633950

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.