ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Efficacy and safety of gonioscopy-assisted transluminal trabeculotomy in glaucoma secondary to fuchs uveitis syndrome: a multicenter study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the long-term surgical outcomes of gonioscopy-assisted transluminal trabeculotomy (GATT) in patients with Fuchs uveitis syndrome (FUS)-associated open-angle glaucoma.
methodsIn this multicenter, retrospective, non-comparative study, 34 consecutive eyes of 31 patients with open-angle glaucoma secondary to FUS who underwent GATT at three tertiary referral centers were included. Patients had inadequate intraocular pressure (IOP) control despite maximal medical therapy and a minimum follow-up of 12 months. Complete success was defined as IOP < 21 mmHg with ≥ 20% reduction from baseline without medication. Qualified success was defined as IOP < 21 mmHg with a ≥ 20% reduction, with or without medication, and no need for additional IOP-lowering surgery. Kaplan-Meier survival analysis was performed to assess cumulative success.
resultsMean preoperative IOP was 34.9 ± 8.0 mmHg on 3.5 ± 0.7 medications. The mean follow-up duration was 28 ± 7.4 months (range, 12-48). At final visit, mean IOP decreased to 15.7 ± 4.0 mmHg (52.7% reduction; p < 0.001), and medication burden decreased to 1.1 ± 1.2 (70.4% reduction; p < 0.001). The cumulative probability of qualified success was 88.2%, and complete success was 41.2% at 24 months. Hyphema occurred in 14.7% of eyes, and IOP spikes were observed in 14.7%; all were transient. Four eyes (11.8%) required additional glaucoma surgery. No significant loss of visual acuity was observed.
conclusionsGATT appears to be a safe and effective surgical option for achieving sustained IOP reduction and decreasing medication burden in FUS-associated glaucoma. Its minimally invasive and conjunctival-sparing nature makes it a reasonable initial surgical strategy in selected patients.
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