Evidence map›Paper›PMID 42470463›Full record

ArticleAnalytical and bioanalytical chemistry2026

Enhanced quantification of 64 pesticides in cannabis-derived oil by isotope-dilution LC-MRM-MS at regulatory decision thresholds.

Raymond T Suhandynata, Jiaxi Cai, Benjamin J Spiegel, Thomas D Marcotte, Igor Grant, Robert L Fitzgerald, Jeremiah D Momper

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Raymond T SuhandynataDepartment of Pathology, University of California San Diego, San Diego, USA. rtsuhandynata@health.ucsd.edu.
Jiaxi CaiShu Chien-Gene Lay Department of Bioengineering, Jacobs School of Engineering, University of California San Diego, San Diego, USA.
Benjamin J SpiegelCenter for Medicinal Cannabis Research Reference Laboratory, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, USA.
Thomas D MarcotteCenter for Medicinal Cannabis Research, Department of Psychiatry, University of California San Diego, San Diego, USA.
Igor GrantCenter for Medicinal Cannabis Research, Department of Psychiatry, University of California San Diego, San Diego, USA.
Robert L FitzgeraldDepartment of Pathology, University of California San Diego, San Diego, USA.
Jeremiah D MomperCenter for Medicinal Cannabis Research Reference Laboratory, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, San Diego, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cannabis legalization has created regulated markets requiring residual pesticide testing to protect public health. Regulatory programs establish action limits governing product release and enforcement, necessitating accurate quantification in analytically challenging matrices. Compliance is further complicated by the need to quantify dozens of compounds with widely varying physicochemical properties, often requiring multiple assays per product. Validated multiplex methods in representative matrices are therefore critical for defensible quantification at regulatory thresholds. We developed and validated a multiplex liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantification of 64 pesticides in cannabis-derived hemp oil, employing external calibration with 58 stable isotope-labeled internal standards (SIL-IS) and 4 surrogate internal standards (IS) across 8.4 units of LogP. Validation followed Clinical & Laboratory Standards Institute (CLSI) guidelines (C62-A, EP05-A3, EP29-A) and Food and Drug Administration (FDA) guidance. All 64 pesticides demonstrated linear calibration (R

Indexed as

CannabisLiquid Chromatography-Mass SpectrometryPesticide ResiduesPesticidesPlant OilsTandem Mass SpectrometryCalibrationChromatography, LiquidLimit of DetectionReproducibility of ResultsPesticide ResiduesPesticidesPlant OilsCannabisIsotope-dilution mass spectrometryLiquid chromatography-mass spectrometryPesticidesStable-isotope

Identifiers

PMID42470463
PMCPMC13585869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.