Evidence map›Paper›PMID 42470302›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Chemically Programmed Prodrug Nanoparticles for Precise Oral Dopamine Delivery to Deep Brain Regions in Parkinson's Disease.

Cam-Hoa Mac, Yu-Wei Chiang, Hong-Nhung Nguyen, Jui-To Wang, Li-An Chu, Ya-Hui Lin, Van Khanh Nguyen, Sheng-Yao Peng, Shih-Kai Lo, Yen Chang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cam-Hoa MacDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.ORCID https://orcid.org/0009-0008-0260-2087
Yu-Wei ChiangDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Hong-Nhung NguyenDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Jui-To WangDepartment of Neurosurgery, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan.
Li-An ChuDepartment of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Ya-Hui LinDepartment of Biomedical Engineering, National Taiwan University, Taipei, Taiwan.
Van Khanh NguyenDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Sheng-Yao PengDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.ORCID https://orcid.org/0009-0003-8325-5008
Shih-Kai LoDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Yen ChangDivision of Cardiovascular Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
Mai Thanh Thi NguyenFaculty of Chemistry, University of Science, Vietnam National University-Ho Chi Minh City, Ho Chi Minh City, Vietnam.ORCID https://orcid.org/0000-0001-8006-4028
Qian Yao ZhangDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.
Yu-Jung LinResearch Center for Applied Sciences, Academia Sinica, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-2507-3551
Hsing-Wen SungDepartment of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan.ORCID https://orcid.org/0000-0002-0789-5236

Funding

National Science and Technology Council of Taiwan 114-2314-B-007-009-MY3National Science and Technology Council of Taiwan NSTC-113-2311-B-007-013National Science and Technology Council of Taiwan NSTC-114-2314-B-007-003National Science and Technology Council of Taiwan NSTC-114-2639-E-007-001-ASP
6 · The paper itself

Abstract

Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic neurons in the inflamed substantia nigra, resulting in striatal dopamine (DA) depletion and severe motor dysfunction. Here, we report a chemically programmed, inflammation-responsive prodrug nanoparticle (NP) system-β-glucans-DA(OAc)

Indexed as

BrainDopamineDrug CarriersNanoparticlesParkinson DiseaseProdrugsAdministration, OralAnimalsbeta-GlucansMiceReactive Oxygen Speciesbeta-GlucansDopamineDrug CarriersProdrugsReactive Oxygen Speciesdopaminergic therapygut‐to‐brain deliverymacrophage‐mediated transportParkinson's diseaseprodrug nanoparticle

Identifiers

PMID42470302
PMCPMC13508734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.