Observational studyClinical cardiology2026
Spontaneous Coronary Reperfusion in STEMI After Pre-Hospital Loading Dose of Triple Antithrombotic Therapy.
Observational study in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
13 authors.
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Abstract
backgroundTo evaluate the incidence and prognosis of spontaneous coronary reperfusion in STEMI using pre-hospital loading dose of P2Y12 inhibitors.
methodsThis prospective bi-centric study included STEMI patients who referred for primary PCI from June 1, to November 1, 2022. All patients received before hospital admission loading dose of aspirin, heparin and P2Y
resultsWithin the study period, 263 patients were admitted with ongoing STEMI and 49 of them (18.6%) had spontaneous coronary reperfusion with no significant difference between loading dose of ticagrelor (n = 226; 85.9%) or clopidogrel (n = 27, 10.3%) and TIMI 3 flow (n = 41; 18.1% vs. n = 7; 25.9%, p = 0.53; respectively). Peak of T-hs troponin (p < 0.001) and CRP (p = 0.03) were significantly lower in the TIMI 3 group. In multivariate analysis, out-of- hospital cardiac arrests were observed twice as often in the TIMI 3 group (16.33 vs. 7.01%; p = 0.044). There was no significant difference between the two groups regarding major in-hospital (p = 0.69) or 1-year major events (p = 0.20).
conclusionSpontaneous reperfusion at admission was observed in about 20% of STEMI patients who received a pre-hospital loading dose of antithrombotic therapy including P2Y
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