Evidence map›Paper›PMID 42470230›Full record

ArticleMagnetic resonance in medicine2026

Brain Clearance of Contrast Agent in Intravenous DCE-MRI Is Measurable and Cannot Be Explained by Clearance Across the BBB Alone.

Martin Kozár, Ioana-Emilia Mosneag, Sarah Al-Bachari, Igor Chernyavsky, Geoff J M Parker, Hervé Boutin, Laura M Parkes, Ingo Schiessl, Ben R Dickie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martin KozárDivision of Imaging, Informatics and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0002-6246-8288
Ioana-Emilia MosneagDivision of Imaging, Informatics and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-0993-8583
Sarah Al-BachariDepartment of Clinical and Movement Neurosciences, University College London, London, UK.
Igor ChernyavskyDepartment of Mathematics, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester, Manchester, UK.
Geoff J M ParkerQuantitative Imaging Group, UCL Hawkes Institute, Department of Medical Physics & Biomedical Engineering, University College London, London, UK.ORCID https://orcid.org/0000-0003-2934-2234
Hervé BoutinGeoffrey Jefferson Brain Research Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Laura M ParkesGeoffrey Jefferson Brain Research Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID https://orcid.org/0000-0001-6488-507X
Ingo SchiesslGeoffrey Jefferson Brain Research Centre, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Ben R DickieDivision of Imaging, Informatics and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0001-5018-2111

Funding

Medical Research Council DTP Studentship: MR/N013751/1Sydney Driscoll Neuroscience Foundation and the Engineering and Physical Sciences Research Council EP/M005909/1
6 · The paper itself

Abstract

purposeTo determine the feasibility of measuring brain clearance of gadolinium contrast agent using standard intravenous DCE-MRI acquisitions and evaluate the contribution of blood-brain barrier (BBB) and non-BBB clearance routes.

methodsUptake and extended Tofts models were fit to DCE-MRI data from people with Parkinson's disease, post-stroke and controls. Models were compared using the Akaike information criterion. Key parameters (K

resultsThe extended Tofts model provided a superior fit compared to all uptake-only models. Extended Tofts estimates of the extravascular extracellular volume fraction v

conclusionModeling clearance of extravasated contrast agent from the brain improves fit quality compared to models that neglect clearance. Estimates of interstitial volume fraction were underestimated at low K

Indexed as

Blood-Brain BarrierBrainContrast MediaDynamic Contrast Enhanced Magnetic Resonance ImagingMagnetic Resonance ImagingParkinson DiseaseAnimalsFeasibility StudiesFemaleHumansMaleMetabolic Clearance RateMiceReproducibility of ResultsStrokeContrast Media

Identifiers

PMID42470230
PMCPMC13527286

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.