ArticleParasites & vectors2026
Comparative speed of kill of induced Ixodes scapularis infestations following treatment of dogs with endectocides containing either sarolaner (Simparica Trio™), afoxolaner (NexGard
Article in Parasites & vectors, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIxodes scapularis is a consequential tick species in North America that can transmit multiple pathogens of canine and public health significance. Acaricidal speed is critical for reducing the risk of pathogen transmission. Herein, the immediate and sustained acaricidal speed of three monthly oral endectocide products against I. scapularis are compared.
methodsThirty-two dogs were randomly allocated equally among four groups and treated on day 0 with an endectocide containing lotilaner (Credelio Quattro™), afoxolaner (NexGard® PLUS) or sarolaner (Simparica Trio™), or left untreated. On days -2, 21, and 28, dogs were infested with 50 laboratory-reared, adult I. scapularis. Live tick counts were performed at 4, 8, 12, 24, and 48-h post-treatment, and after each reinfestation. Efficacy was compared using a linear mixed model of geometric mean live tick counts.
resultsAt 8-h post-treatment of an existing infestation, only the lotilaner group had significantly lower mean live tick counts than the untreated group. At each subsequent assessment through 48 h, all treated groups had significantly lower mean live tick counts than the untreated group. Compared to the untreated group, following the day 21 reinfestation, mean live tick counts were significantly lower in the lotilaner group at 4 through 48 h, in the sarolaner group at 4, 24, and 48 h, and in the afoxolaner group at 24 and 48 h. Compared to the untreated group, following the day 28 reinfestation, mean live tick counts were significantly lower in the lotilaner group at 8 through 48 h, in the sarolaner group at 12 through 48 h and, in the afoxolaner group at 24 and 48 h. Within group, between day 0 and day 28, significant slowing of acaricidal speed was observed for sarolaner at the 12-h timepoint and for afoxolaner at the 8, 12, and 24-h timepoints. No significant loss of acaricidal speed occurred for lotilaner between day 0 and day 28.
conclusionsIn dogs, lotilaner has a faster onset of acaricidal activity against I. scapularis than sarolaner or afoxolaner. Lotilaner's acaricidal speed is sustained throughout the monthly dosing interval, whereas sarolaner and afoxolaner show slower acaricidal activity at the end of the month than at the beginning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.