Evidence map›Paper›PMID 42469899›Full record

ReviewJournal of cardiothoracic surgery2026

Improving outcomes in myasthenia gravis: uni-portal video-assisted thoracoscopic (UVATS) thymectomy in a single-centre retrospective cohort.

A Rahim, I Samsudin, M Menon, J X Hoo, T Jayaselan, J Y Ooi, Z S Nicolas Ong, C D Sudarshan, S Krishnasamy

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A RahimDepartment of Surgery, Division of Cardiothoracic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.
I SamsudinDepartment of Surgery, Division of Cardiothoracic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.
M MenonDepartment of Surgery, Division of Cardiothoracic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.
J X HooDepartment of Surgery, Division of Cardiothoracic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.
T JayaselanFaculty of Medicine, MAHSA University, Selangor, Malaysia.
J Y OoiFaculty of Medicine, MAHSA University, Selangor, Malaysia.
Z S Nicolas OngFaculty of Medicine, MAHSA University, Selangor, Malaysia.
C D SudarshanDepartment of Surgery, Division of Cardiothoracic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia.
S KrishnasamyDepartment of Surgery, Division of Cardiothoracic Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603, Malaysia. sivakumar@ummc.edu.my.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThymectomy is a well-established treatment for myasthenia gravis (MG), with minimally invasive approaches increasingly preferred due to reduced morbidity. This study evaluates the safety and clinical outcomes of uni-portal video-assisted thoracoscopic surgery (UVATS) thymectomy in MG patients at a Malaysian tertiary centre.

methodsWe conducted a retrospective cohort study of 30 patients who underwent UVATS thymectomy for MG at Universiti Malaya Medical Centre between August 2016 and July 2025. Of these, 24 patients with complete perioperative and follow-up data were included. Outcomes assessed included postoperative complications, length of stay, disease severity by Modified Osserman classification, medication requirements, and symptomatic improvement.

resultsThe cohort (58% female, mean age 42.5 ± 18.2 years) had 50% thymoma. Postoperatively, 88% demonstrated clinical improvement. Osserman Class I proportion increased from 8% preoperatively to 75% postoperatively (p < 0.001). Corticosteroid dependency decreased from 75% to 33% (p = 0.003), pyridostigmine from 67% to 29%. Mean hospital stay was 3.4 ± 1.2 days. Complication rate was 8% (all minor), with no perioperative mortality.

conclusions"UVATS thymectomy is safe and demonstrates favorable short-term clinical outcomes in appropriately selected MG patients as the result has demonstrated significant clinical improvement, reduced medication requirements, and low morbidity. These findings support UVATS as the preferred minimally invasive approach in suitable candidates.

Indexed as

Myasthenia GravisThoracic Surgery, Video-AssistedThymectomyAdultFemaleHumansLength of StayMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment OutcomeYoung AdultMinimally invasive surgeryMyasthenia gravisThymectomyUniportalVATS

Identifiers

PMID42469899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.