Evidence map›Paper›PMID 42469839›Full record

ArticleBMC health services research2026

Strategies to address implementation barriers in sepsis survivors' care transitions to home health and outpatient care: a multi-site, type 1 hybrid implementation study.

Kathryn H Bowles, Karen B Hirschman, Michael A Stawnychy, Melissa O'Connor, Mark E Mikkelsen, Sang Bin You, Elaine Sang, Sungho Oh, Katherine Pitcher, Brittany Newman and 3 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in BMC health services research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kathryn H BowlesDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA. bowles@nursing.upenn.edu.
Karen B HirschmanDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Michael A StawnychyDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Melissa O'ConnorDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Mark E MikkelsenUniversity of Colorado Anschutz Medical Campus, Fitzsimons Building 13001 East 17th Place, Room E1354 Campus Box C290, Aurora, CO, USA.
Sang Bin YouDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Elaine SangDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Sungho OhDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Katherine PitcherDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Brittany NewmanCollege of Arts and Sciences, University of Pennsylvania, 249 S 36th Street, Philadelphia, PA, USA.
Charlotte WeissDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Chaerin LeeDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.
Nancy HodgsonDepartment of Biobehavioral Health Science, NewCourtland Center for Transitions & Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA, 19104, USA.

Funding

Individualized Care for At Risk Older AdultsT32NR009356 · NINR · UNIVERSITY OF PENNSYLVANIA · PI Lauren M Massimo, MARY D NAYLOR · 2007 to 2026
$7.8M
Sepsis Patient Education: Perspectives from Home Health Nurses and Knowledge among Sepsis SurvivorsF31NR021242 · NINR · UNIVERSITY OF PENNSYLVANIA · PI SANG, ELAINE · 2024 to 2025
$96k
NIA NIH HHS 1F99AG095132NINR NIH HHS 2R01NR016014NINR NIH HHS F31 NR021242NINR NIH HHS T32NR009356
6 · The paper itself

Abstract

backgroundTimely attention by home health care (HHC) and outpatient providers within one week after hospital discharge is associated with lower readmission rates among sepsis survivors. However, few patients nationwide receive this pattern of care. Improving care transitions for sepsis survivors is inhibited by barriers in sepsis identification, information transfer, care coordination, timely access to care, and patient engagement. The I-TRANSFER study was designed to address these gaps by implementing timely delivery of post-acute care (PAC) for sepsis survivors in real-world health care settings. The study aimed to identify, describe, and map the implementation strategies used to implement the I-TRANSFER care transition protocol.

methodsFive diverse health systems (16 hospitals), partnered with an affiliated HHC agency, participated in a Type 1 hybrid implementation science study. Through thematic inductive and deductive qualitative analysis, implementation determinants-barriers and facilitators-were identified, summarized, and presented back to the sites' implementation teams. This paper reports on implementation strategies used to address barriers and implement the I-TRANSFER care transition protocol. Strategies are mapped to the Expert Recommendations for Implementing Change (ERIC) taxonomy.

resultsImplementors and researchers deployed strategies spanning 62% of the 73 ERIC categories, resulting in hundreds of detailed examples. Strategies aimed at identifying sepsis and referring survivors to HHC emphasized relaying clinical data to providers; adjusting the EHR; and educating staff to improve sepsis recognition, documentation, and referral to HHC. Strategies aimed at information transfer and making outpatient appointments emphasized EHR-based tools, telemedicine workflows, and centralized scheduling to ensure communication to PAC and timely outpatient appointments. Providing timely HHC and outpatient visits required staff and patient education, tailored HHC pathways, patient-focused interventions, and quality monitoring. Cross-cutting strategies reinforced coordination and education across the full continuum of care. Heat maps illustrate which strategies were used most often across objectives and by hospital/HHC dyad.

conclusionsThis study identified, described, and mapped to the ERIC taxonomy more than 450 implementation strategies used by hospital-HHC dyads to implement the I-TRANSFER care transition protocol, providing practical, translatable strategies to support timely post-acute care transitions for sepsis survivors. By identifying the barriers in care transitions, and reporting the strategies to address them, these findings can inform broader efforts to deliver timely, coordinated care and improve outcomes for vulnerable populations across settings.

Indexed as

Ambulatory CareContinuity of Patient CareHome Care ServicesPatient TransferSepsisSurvivorsHumansImplementation ScienceQualitative ResearchCare coordinationExpert Recommendations for Implementing Change (ERIC)Healthcare deliveryHome health careHybrid-effectiveness implementation studyInformation transferOutpatient follow-upPost-acute careSepsis survivorshipTransitional care

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.